Toxicity Working Documents
EC Working document on setting dermal absorption values for operators, workers and bystanders and comparing with AOEL's
CRD Applicant guidance links:
EC guidance documents:
Other relevant guidance:
Operator Exposure Guidance
Full guidance to enable applicants to generate Operator Exposure overviews for the submission of applications can be found here.
Two Operator Exposure Models are now available on the CRD website. Both new models have been designed to be easier to use than the previously available versions and feature pull-down pick lists, automated input fields for certain parameters and error messages to highlight when invalid options have been selected.
The UK Predictive Operator Exposure Model (POEM)
This is in the form of a Microsoft Excel workbook containing 3 pages: operating instructions, a model for liquid concentrate formulations and a model for solid concentrate formulations. In the latter, dermal and inhalation exposure during mixing and loading is based on values from the German model. In previous versions of the UK POEM , exposure values for the mixing and loading of solid formulations were assumed to be identical to those for liquid concentrates.
This model differs from the previous version of the UK POEM by including new information relating to home garden uses, an extended range of packaging options (for liquid concentrate formulations only) and an additional option for the use of impermeable coveralls when using knapsack sprayers or hand-held Controlled Droplet Application (CDA) lances.
The German Operator Exposure Model (BBA 1992).
CRD's interpretation of the German Operator Exposure Model (BBA 1992)
This is in the form of a Microsoft Excel workbook containing 2 pages: operating instructions and a model based on geometric mean values (appropriate for EC regulatory use).
For each model, more detailed information is provided in the operating instructions page of the workbook.